|
KMID : 1101720140180020225
|
|
Physical Activity and Nutrition
2014 Volume.18 No. 2 p.225 ~ p.233
|
|
|
The effect of treadmill exercise on inflammatory responses in rat model of streptozotocin-induced experimental dementia of Alzheimer’s type
|
|
Choi Dong-Hun
Kwon In-Su
Koo Jung-Hoon
Jang Yong-Chul
Kang Eun-Bum
Byun Jung-Eun
Um Hyun-Sub
Park Hoo-Seong
Yeom Dong-Cheol
Cho In-Ho
Cho Joon-Yong
|
|
|
Abstract
|
|
|
[Purpose] The aim of this study was to investigate the effect of treadmill exercise on inflammatory response in streptozotocin (STZ)-induced animal model of Alzheimer’s disease (AD).
[Methods] To induce the animal model of AD, Sprague-Dawley rats were injected into intracerebroventricular (ICV) injection with 1.5 mg/kg of STZ. Rats were divided into three groups as Sham-con group (n = 7), STZ-con group (n = 7) and STZ-exe group (n = 7). Exercise group ran on the treadmill for 30 min/day, 5 days/week during 6 weeks.
[Results] The results of this study were as follows: First, STZ-exe group was improved on cognitive function when compared to STZ-con group in water maze test. Second, STZ-exe group help reduce the expression level of amyloid-beta (Aβ). In addition, Toll-like receptors-4 (TLR4), Nuclear factor-kB (NF-kB), Tumor necrosis factor-α (TNF-α) and Interleukin-1α (IL-1α) level of STZ-exe group was significantly decreased when compared to STZ-con group.
[Conclusion] These results show that treadmill exercise had positive effect on cognitive function and reduced inflammatory response in STZ-induced animal model of AD.
|
|
|
KEYWORD
|
|
|
Streptozotocin, Alzheimer’s disease, Treadmill exercise, Amyloid-beta, Inflammatory
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|